4,4'-Dimethoxytrityl chloridei-nucleoside enamandla kunye neqela le-nucleotide elikhuselayo kunye nokuphelisa i-agent.
Isithethantonye:DMT-Cl
Inombolo ye-CAS:40615-36-9
Iipropati
Ifomula yeMichiza
Ubunzima beMolekyuli
Ubushushu boGcino
Indawo yokunyibilika
Ubunyulu
Umphandle
C21H19ClO2
338.82 g/mol
2~8℃
120-125℃
≥98%
Ikristale ePinki
Njengamacandelo abalulekileyo amakhonkco e-nucleic acid, i-nucleosides kunye ne-nucleotides zidlala indima ebalulekileyo ekuhanjisweni kolwazi lwemfuza.Nangona kunjalo, ngenxa ye-reactivity yabo yeekhemikhali kunye nokuthotywa lula, i-nucleosides kunye ne-nucleotides zifuna ii-reagents ezikhethekileyo ukuze zikhuseleke ngexesha lokudibanisa.I-DMTCl4' Dimethoxytrityl (DMTCl) liqela elisebenza kakhulu elikhuselayo kunye nokuphelisa i-arhente eye yaguqula ukhuseleko lwee-nucleosides kunye neenucleotides ngexesha lokudibanisa.
I-DMTCl yi-agent ekhuselayo ye-hydroxyl esabela ngokukhethiweyo kunye namaqela e-hydroxyl e-nucleosides kunye nee-nucleotides ngexesha lokudibanisa ukwenza iqela elikhuselayo lexeshana elithintela ii-nucleosides kunye nee-nucleotides ekubeni zingasebenzi kunye nezinye iikhemikhali.Eli qela lokukhusela lexeshana lisuswa ngokulula emva kokuhlanganiswa, lishiya i-nucleosides ecocekileyo okanye i-nucleotides.
Ngenxa yokusebenza kakuhle kwayo kunye nokukhetha kwayo,I-DMTClisetyenziswa ngokubanzi njengeqela elikhuselayo kunye nokuphelisa i-agent kwi-synthesis ye-DNA, i-RNA kunye nezinye i-nucleic acids.Kubaluleke kakhulu kwi-oligonucleotide synthesis apho ulawulo oluchanekileyo phezu kwendawo ye-nucleotide kunye nokulandelelana kuyadingeka.
Ukongeza ekusebenzeni njengomkhuseli weqela kunye ne-eliminator, i-DMTCl ngumkhuseli onamandla we-hydroxyl we-nucleosides kunye ne-nucleotides.Ikhusela amaqela e-hydroxyl e-nucleosides kunye ne-nucleotides kwi-oxidation, ukunciphisa, kunye nezinye iimpendulo ezinokuzonakalisa ngexesha lokudibanisa.
Isishwankathelo,I-DMTCl4 4' dimethoxytritylsisixhobo esibalulekileyo sokwenziwa kweenucleosides kunye neenucleotides.Ukusebenza kwayo okugqwesileyo, ukukhetha kunye nokuguquguquka kwenza kube liqela elifanelekileyo elikhuselayo kunye nokuphelisa i-agent kunye ne-agent ekhuselayo ye-hydroxyl ye-DNA, i-RNA kunye nezinye i-nucleic acid synthesis.Ukuba ufuna umgangatho ophezulu kunye nokhuseleko oluthembekileyo lwee-nucleosides kunye neenucleotides ngexesha lokudibanisa, ungajongi ngaphaya kwe-DMTCl.
Ixesha lokuposa: Jun-08-2023