Formamidine acetate, eyaziwa ngokuba yi-N, N-dimethylformamidine acetate okanye i-CAS No. 3473-63-0, i-compound ebalulekileyo edlala indima ebalulekileyo ekuphuhlisweni kweziyobisi.Le khemikhali iye yatsala ingqalelo enkulu kwishishini lamachiza ngenxa yeempawu zayo ezininzi kunye nezicelo ezinokubakho zonyango.
Enye yezinto eziphambili ze-formamidine acetate kukukwazi ukwenza njengesiseko esomeleleyo kunye ne-nucleophile.Oku kuthetha ukuba inokuthatha inxaxheba ngokusebenzayo kwiinguqu zemichiza, iyenza ibe licandelo elibalulekileyo ekudityanisweni kwamayeza amaninzi.I-reactivity yayo ekhethekileyo ivumela ukuba isetyenziswe kwiintlobo ezahlukeneyo zezicelo zamachiza, kubandakanywa nophuhliso lwe-antiviral, antibacterial and antifungal drugs.
Formamidine acetateibonise amandla amakhulu njenge-arhente ye-antiviral.Umsebenzi wayo ngokuchasene ne-DNA kunye neentsholongwane ze-RNA, kuquka i-herpes simplex virus (HSV) kunye ne-human immunodeficiency virus (HIV), ifundwe ngokubanzi.Abaphandi bafumanise ukuba ikhompawundi inqanda ukuphindaphindwa kwentsholongwane ngokuphazamisa i-enzymes yentsholongwane, ngaloo ndlela ivalela amandla abo okuphindaphinda ngaphakathi kweeseli zomkhosi.Ukunika inkxalabo ekhulayo malunga nokuqhambuka kwentsholongwane kunye nesidingo sonyango olusebenzayo lwe-antiviral, i-formamidine acetate kulindeleke ukuba ibe ngumgqatswa onokubakho kuphuhliso lwamachiza e-antiviral anoveli.
Ukongezelela, i-formamidine acetate ibonise iipropati ezinamandla ze-antimicrobial.Ifundwe ngokusebenza kwayo kwiintlobo ezahlukeneyo zebhaktheriya, zombini i-Gram-positive kunye ne-Gram-negative.Uphononongo lubonise ukuba le khompawundi inokuphazamisa i-bacterial cell membranes, inqanda ukukhula kwebhaktheriya kunye nokuzala.Ikwafunyaniswe ukuba yonyusa ukusebenza kwe-antibiotics esele ikhona, iyenza ibe sisixhobo esinokubakho kumlo ochasene ne-antibiotic-resistant bacteria.
Esinye isicelo esibalulekileyo seformamidine acetateilele kumandla ayo e-antifungal.Usulelo lomngundo lubeka isoyikiso esikhulu kwimpilo yabantu, ngakumbi kubantu abakhubazekileyo.Ikhompawundi ibonise iziphumo ezithembisayo ekuvimbeleni ukukhula kwefungi ye-pathogenic ngokuphazamisa i-membrane zabo zeseli kunye nokuphazamisa iindlela zabo ze-metabolic.Njengoko ukuchasana kwefungal kumachiza e-antifungal yangoku kuya kuxhaphaka ngakumbi, i-formamidine acetate ibonelela ngendlela entsha yokuphuhliswa kwamachiza e-antifungal.
I-acetate ye-Formamidine iphinda isetyenziswe njengento engundoqo ephakathi kwi-synthesis yamachiza amaninzi amayeza.Ubume bayo obukhethekileyo beekhemikhali kunye nokusebenza kwakhona kwenza kube yinto efanelekileyo ekrwada yokuvelisa amayeza ahlukeneyo.Ngaphaya koko, ukudityaniswa kwayo okusebenzayo kunye nokufikeleleka kunegalelo ekudumeni kwayo kuphuhliso lwamachiza.
Ukuququmbela,formamidine acetatengenombolo ye-CAS 3473-63-0 idlala indima ebalulekileyo kuphuhliso lwamachiza.Ukukwazi ukusebenza njengesiseko esomeleleyo kunye ne-nucleophile, kunye ne-antiviral enamandla, i-antibacterial, kunye ne-antitifungal properties, yenza ukuba ibe ngumviwa onomdla wokuphuhliswa kwee-agent zonyango zonyango.Ukuphononongwa okuqhubekayo kwe-formamidine acetate kuphando lwamachiza kuzisa ithemba elikhulu lokufunyanwa kweziyobisi kwixesha elizayo kunye nokunyangwa kwezifo ezahlukeneyo ezosulelayo.
Ixesha lokuposa: Jun-20-2023