Tetrabutylammonium iodidei-reagent esetyenziswa ngokubanzi kwiindlela ezahlukeneyo zeekhemikhali.Enye yezona zinto zinomdla kwaye zifundwe ngokubanzi izicelo ze-TBAI kukusetyenziswa kwayo ekudibaneni kwee-azides.
Isithethantonye:I-TBAI
Inombolo ye-CAS:311-28-4
Iipropati
Ifomula yeMichiza
C16H36IN
Ubunzima beMolekyuli
369.37g/mol
Ubushushu boGcino
Indawo yokunyibilika
141-143℃
Ubunyulu
≥98%
Umphandle
ikristale emhlophe okanye umgubo omhlophe
I-Tetrabutylammonium iodide, ekwabizwa ngokuba yi-TBAI, sisixhobo esisetyenziswa ngokubanzi kwiindlela ezahlukeneyo zemichiza.Enye yezona zinto zinomdla kwaye zifundwe ngokubanzi izicelo ze-TBAI kukusetyenziswa kwayo ekudibaneni kwee-azides.Kodwa yintoni inkqubo esemva kwale mpendulo, kwaye i-TBAI inegalelo njani kuyo?
Indlela yokuphendula ye-TBAI intsonkothile kwaye ibandakanya amanyathelo angundoqo aliqela.Ngokubanzi, le mpendulo ibandakanya i-in situ isizukulwana se-hypoiodite evela kwi-TBAI kunye ne-co-reactant eyaziwa ngokuba yi-TBHP.Le hypoiodite emva koko isabela kunye nekhompawundi ye-carbonyl ukwenza i-intermediate ethi emva koko i-azide.Ekugqibeleni, i-hypoiodite iphinda ihlaziywe kwakhona nge-oxidation.
Isinyathelo sokuqala kwindlela yokusabela ibandakanya ukuveliswa kwe-hypoiodite evela kwi-TBAI kunye ne-TBHP.Eli linyathelo elibalulekileyo kuba liqalisa ukusabela ngokubonelela ngeentlobo ze-iodine eziyimfuneko kwi-carbonyl oxidation elandelayo.IHypoiodate iyasebenza kakhulu kwaye iyakwazi ukukhuthaza ukusabela kweekhemikhali ezininzi ezahlukeneyo, kubandakanya i-halogenation kunye ne-oxidation.
Nje ukuba i-hypoiodite yenziwe, isabela kunye nekhompawundi ye-carbonyl ukuze yenze indawo ephakathi.Le intermediate ke azidated kusetyenziswa reagent imide, leyo yongeza iiathom nitrogen ezimbini kwi molekyuli kwaye ngokusisiseko "isebenze" ukuze asabele ngakumbi.Okwangoku, i-TBAI isebenze injongo yayo kwaye ayisadingeki ekuphenduleni.
Isinyathelo sokugqibela kwindlela ibandakanya ukuhlaziywa kwe-hypoiodite.Oku kuphunyezwa nge-oxidation usebenzisa i-co-reactants efana ne-hydrogen peroxide.Ukuhlaziya i-hypoiodite kubalulekile kuba ivumela impendulo ukuba iqhubeke nokuhamba ngebhayisikile kwaye ivelise i-azides eninzi.
Lilonke, indlela yokuphendula ye-TBAI intle kakhulu kwaye iyasebenza.Ngokuvelisa i-hypoiodite kwi-situ kwaye isebenzise i-oxidize iikhompawundi ze-carbonyl, i-TBAI yenza ukuba ukuveliswa kwee-azides kunokuba nzima okanye akunakwenzeka ukwenza.Nokuba ungusokhemisti osebenza kwilabhoratri yophando okanye umenzi ojonge ukuvelisa izinto ezintsha, i-TBAI inokuninzi enokunikezela.Yizame namhlanje!
Ixesha lokuposa: Jun-14-2023